Viruses, Vol. 13, Pages 1441: Serological Evidence of Widespread Zika Transmission across the Philippines

Viruses, Vol. 13, Pages 1441: Serological Evidence of Widespread Zika Transmission across the Philippines Viruses doi: 10.3390/v13081441 Authors: Joseph R. Biggs Ava Kristy Sy Oliver J. Brady Adam J. Kucharski Sebastian Funk Yun-Hung Tu Mary Anne Joy Reyes Mary Ann Quinones William Jones-Warner James Ashall Ferchito L. Avelino Nemia L. Sucaldito Amado O. Tandoc Eva Cutiongco-de la Paz Maria Rosario Z. Capeding Carmencita D. Padilla Martin L. Hibberd Julius Clemence R. Hafalla Zika virus (ZIKV) exposure across flavivirus-endemic countries, including the Philippines, remains largely unknown despite sporadic case reporting and environmental suitability for transmission. Using laboratory surveillance data from 2016, 997 serum samples were randomly selected from suspected dengue (DENV) case reports across the Philippines and assayed for serological markers of short-term (IgM) and long-term (IgG) ZIKV exposure. Using mixture models, we re-evaluated ZIKV IgM/G seroprevalence thresholds and used catalytic models to quantify the force of infection (attack rate, AR) from age-accumulated ZIKV exposure. While we observed extensive ZIKV/DENV IgG cross-reactivity, not all individuals with active DENV presented with elevated ZIKV IgG, and a proportion of dengue-negative cases (DENV IgG-) were ZIKV IgG-positive (14.3%, 9/63). We identified evidence of long-term, yet not short-term, ZIKV exposure across Philippine regions (ZIKV IgG+: 31.5%, 314/997) w...
Source: Viruses - Category: Virology Authors: Tags: Article Source Type: research