Vitamin K and cardiovascular complications in CKD patients

Vitamin K, well known for its role in coagulation, encompasses two major subgroups: Vitamin K1 is exclusively synthesized by plants, whereas vitamin K2 mostly originates from bacterial synthesis. Vitamin K serves as a cofactor for the enzyme γ-glutamyl carboxylase, which carboxylates and thereby activates various vitamin K dependent proteins. Several vitamin K–dependent proteins are synthesized in bone but the role of vitamin K for bone health in CKD patients, in particular the prevention of osteoporosis is still not firmly establish ed.

Source: Kidney International - July 23, 2021 Category: Urology & Nephrology Authors: N. Kaesler, L.J. Schurgers, J. Floege Tags: review Source Type: research