Cancers, Vol. 13, Pages 3696: Overview of Oral Potentially Malignant Disorders: From Risk Factors to Specific Therapies

Cancers, Vol. 13, Pages 3696: Overview of Oral Potentially Malignant Disorders: From Risk Factors to Specific Therapies Cancers doi: 10.3390/cancers13153696 Authors: Luigi Lorini Coro Bescós Atín Selvam Thavaraj Urs Müller-Richter Margarita Alberola Ferranti Jorge Pamias Romero Manel Sáez Barba Alba de Pablo García-Cuenca Irene Braña García Paolo Bossi Paolo Nuciforo Sara Simonetti Oral squamous cell carcinoma (OSCC) is a very aggressive cancer, representing one of the most common malignancies worldwide. Oral potentially malignant disorders (OPMDs) regroup a variegate set of different histological lesions, characterized by the potential capacity to transform in OSCC. Most of the risk factors associated with OSCC are present also in OPMDs’ development; however, the molecular mechanisms and steps of malignant transformation are still unknown. Treatment of OSCC, including surgery, systemic therapy and radiotherapy (alone or in combination), has suffered a dramatic change in last years, especially with the introduction of immunotherapy. However, most cases are diagnosed during the advanced stage of the disease, decreasing drastically the survival rate of the patients. Hence, early diagnosis of premalignant conditions (OPMDs) is a priority in oral cancer, as well as a massive education about risk factors, the understanding of mechanisms involved in malignant progression and the development of specific and more efficient therapies. The aim of ...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Review Source Type: research