Cancers, Vol. 13, Pages 3696: Overview of Oral Potentially Malignant Disorders: From Risk Factors to Specific Therapies
Cancers, Vol. 13, Pages 3696: Overview of Oral Potentially Malignant Disorders: From Risk Factors to Specific Therapies
Cancers doi: 10.3390/cancers13153696
Authors:
Luigi Lorini
Coro Bescós Atín
Selvam Thavaraj
Urs Müller-Richter
Margarita Alberola Ferranti
Jorge Pamias Romero
Manel Sáez Barba
Alba de Pablo García-Cuenca
Irene Braña García
Paolo Bossi
Paolo Nuciforo
Sara Simonetti
Oral squamous cell carcinoma (OSCC) is a very aggressive cancer, representing one of the most common malignancies worldwide. Oral potentially malignant disorders (OPMDs) regroup a variegate set of different histological lesions, characterized by the potential capacity to transform in OSCC. Most of the risk factors associated with OSCC are present also in OPMDs’ development; however, the molecular mechanisms and steps of malignant transformation are still unknown. Treatment of OSCC, including surgery, systemic therapy and radiotherapy (alone or in combination), has suffered a dramatic change in last years, especially with the introduction of immunotherapy. However, most cases are diagnosed during the advanced stage of the disease, decreasing drastically the survival rate of the patients. Hence, early diagnosis of premalignant conditions (OPMDs) is a priority in oral cancer, as well as a massive education about risk factors, the understanding of mechanisms involved in malignant progression and the development of specific and more efficient therapies. The aim of ...
Source: Cancers - Category: Cancer & Oncology Authors: Luigi Lorini Coro Besc ós Atín Selvam Thavaraj Urs M üller-Richter Margarita Alberola Ferranti Jorge Pamias Romero Manel S áez Barba Alba de Pablo Garc ía-Cuenca Irene Bra ña García Paolo Bossi Paolo Nuciforo Sara Simonetti Tags: Review Source Type: research
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