Miltefosine enhances infectivity of a miltefosine-resistant < i > Leishmania infantum < /i > strain by attenuating its innate immune recognition

Conclusions/SignificanceDifferential induction of innate immune responses in the liver was found to underlie the attenuated phenotype of a MIL-R parasite and its peculiar feature of drug-dependency. The impact of MIL on hepatic NK and NKT activation and IFN- γ production following recognition of a MIL-R strain indicates that this mechanism may sustain infections with resistant parasites and contribute to treatment failure.

http://feeds.plos.org/~r/plosntds/NewArticles/~3/XIWvgjlN0h8/article

Source: PLoS Neglected Tropical Diseases - July 22, 2021 Category: Tropical Medicine Authors: Dimitri Bult é Source Type: research