Haematological issues in neonates with neonatal encephalopathy treated with hypothermia

Neonatal encephalopathy (NE) is associated with abnormality of neurological function and involves multiorgan dysfunction. There are long-term complications such as cerebral palsy and developmental delay. Cardiac, renal, neurological and other organ dysfunctions are well described. Haematological dysfunction is relatively common and includes anaemia, thrombocytopenia, monocyte and neutrophil activation, hypofibrinogenemia and coagulopathy. There is a lack of consensus definitions of hematological parameters and optimal levels for intervention due to the lack of interventional studies in term neonates and the lack of knowledge of the optimal values during therapeutic hypothermia.

Source: Seminars in Fetal and Neonatal Medicine - July 22, 2021 Category: Perinatology & Neonatology Authors: Eman Isweisi, Carmel Maria Moore, Tim Hurley, Martha Sola-Visner, Naomi McCallion, Fionnuala Ni Ainle, Zunera Zareen, Deirdre U. Sweetman, Anna E. Curley, Eleanor J. Molloy, Newborn Brain Society Guidelines and Publications Committee Source Type: research