Inside-out regulation of E-cadherin conformation and adhesion [Biophysics and Computational Biology]

Cadherin cell–cell adhesion proteins play key roles in tissue morphogenesis and wound healing. Cadherin ectodomains bind in two conformations, X-dimers and strand-swap dimers, with different adhesive properties. However, the mechanisms by which cells regulate ectodomain conformation are unknown. Cadherin intracellular regions associate with several actin-binding proteins including vinculin, which are...

Source: Proceedings of the National Academy of Sciences - July 22, 2021 Category: Science Authors: Ramesh Koirala, Andrew Vae Priest, Chi-Fu Yen, Joleen S. Cheah, Willem-Jan Pannekoek, Martijn Gloerich, Soichiro Yamada, Sanjeevi Sivasankar Tags: Biophysics and Computational Biology Biological Sciences Source Type: research