KRAS4A induces metastatic lung adenocarcinomas in vivo in the absence of the KRAS4B isoform [Genetics]

In mammals, the KRAS locus encodes two protein isoforms, KRAS4A and KRAS4B, which differ only in their C terminus via alternative splicing of distinct fourth exons. Previous studies have shown that whereas KRAS expression is essential for mouse development, the KRAS4A isoform is expendable. Here, we have generated a mouse...

Source: Proceedings of the National Academy of Sciences - July 22, 2021 Category: Science Authors: Marina Salmon, Guillem Paniagua, Carmen G. Lechuga, Fernando Fernandez–Garcia, Eduardo Zarzuela, Ruth Alvarez–Diaz, Monica Musteanu, Carmen Guerra, Eduardo Caleiras, Javier Munoz, Sagrario Ortega, Matthias Drosten, Mariano Barbacid Tags: Genetics Biological Sciences Source Type: research