Retinopathy of prematurity shows alterations in Vegfa < sub > 164 < /sub > isoform expression

CONCLUSIONS: Vegfa164a, Vegfa164b, and Vegfr1 were overexpressed in OIR mice, leading to abnormal signaling and angiogenesis. Furthers studies of mechanisms of Vegf dysregulation may lead to novel therapies for ROP and other proliferative retinopathies.IMPACT: Vegfa164 has two major isoforms, a proangiogenic, Vegfa164a, and an antiangiogenic, Vegfa164b, with opposing receptors, inhibitory Vegfr1, and stimulatory Vegfr2, but their role in OIR is unclear. In Phase 1 OIR, both isoforms and receptors are expressed similarly. In Phase 2 OIR, both isoforms are overexpressed, with an increased ratio of inhibitory Vegfr1. Modulation of angiogenesis by Vegf regulation enables pruning of excess angiogenesis during physiology, but results in ineffective angiogenesis during OIR. Knowledge of VEGF dysregulation may have novel therapeutic implications in the management of ROP and retinal proliferative diseases.PMID:34285351 | DOI:10.1038/s41390-021-01646-9

Source: Pediatric Research - July 21, 2021 Category: Pediatrics Authors: Olachi J Mezu-Ndubuisi Yong-Seok Song Erica Macke Hailey Johnson Ginika Nwaba Akihiro Ikeda Nader Sheibani Source Type: research