Prophylactic nimodipine treatment for hearing preservation after vestibular schwannoma surgery: study protocol of a randomized multi-center phase III trial —AkniPro 2

DiscussionProphylactic parenteral nimodipine treatment may have a positive effect on hearing preservation in VS surgery and would improve patient ’s quality of life. Further secondary analyses are planned. Except for dose-depending hypotension, nimodipine is known as a safe drug. In the future, prophylactic nimodipine treatment may be recommended as a routine medication in VS surgery. VS can be considered as an ideal model for clinical eval uation of neuroprotection, since hearing outcome can be classified by well-recognized criteria. The beneficial effect of nimodipine may be transferable to other surgical procedures with nerves at risk and may have impact on basic research.Trial registrationEudraCT 2019-002317-19,DRKS00019107. 8th May 2020.
Source: Trials - Category: Research Source Type: clinical trials