Prognostic value of the neutrophil-to-lymphocyte ratio in patients with laryngeal squamous cell carcinoma: a meta-analysis

This study aimed to evaluate the prognostic value of NLR among LSCC patients and the association between NLR and clinical characteristics. A systematic search was done through the PubMed, Embase, Scopus, CNKI, Wan Fang, and Web of Science databases. Hazard ratios (HRs) were extracted to estimate the link between NLR and prognosis of LSCC patients, including overall survival (OS), disease-free survival (DFS), and progression-free survival (PFS). Odds ratios (ORs) were used to evaluate the association between NLR and clinical characteristics. Fourteen studies were enrolled in the meta-analysis. The results showed that a high pre-treatment NLR predicted poor OS (HR = 1.80; 95% CI, 1.58–2.06;I2 = 26.1%;P = 0.00), DFS (HR = 1.60; 95% CI, 1.28–2.01;I2 = 0.0%;P = 0.000), and PFS (HR = 1.72; 95% CI, 1.38–2.13;I2 = 4.1%;P = 0.00). In addition, a high pre-treatment NLR was significantly associated with TNM stage (OR = 2.86; 95% CI, 1.82–4.47;I2 = 79.6%;P = 0.000), T stage (OR = 2.37; 95% CI, 1.62–3.48;I2 = 73.4%;P = 0.000), N stage (OR = 2.27; 95% CI, 1.47–3.51;I2 = 74.2%;P = 0.000), and sex (OR = 1.55; 95% CI, 1.15–2.10;I2 = 41.3%;P = 0.004), but not smoking history (OR = 0.95; 95% CI, 0.71–1.28;I2 = 49.2%;P = 0.759) or drinking history (OR = 0.88; 95% CI, 0.61–1.26;I2 = 0.0%;P = 0.492). Pre-treatment NLR may be a potential prognostic biomarker for LSCC patient...
Source: Comparative Clinical Pathology - Category: Pathology Source Type: research