Interventions for the management of abdominal pain in ulcerative colitis

CONCLUSIONS: We found very low-certainty evidence on the efficacy and safety of interventions for the management of abdominal pain in ulcerative colitis. Pervasive issues with very serious imprecision from small samples size and high risk of bias have led to very low-certainty outcomes, precluding conclusions. While few adverse events and no serious adverse events were reported, the certainty of these findings was again very low for all comparisons, so no conclusions can be drawn. There is a need for further research. We have identified eight ongoing studies in this review, so an update will be warranted. It is key that future research addresses the issues leading to reduced certainty of outcomes, specifically sample size and reporting that leads to high risk of bias. It is also important that if researchers are considering pain as a critical outcome, they should report clearly if participants were pain-free at baseline; in that case, data would be best presented as separate subgroups throughout their research.PMID:34291816 | DOI:10.1002/14651858.CD013589.pub2

Source: Cochrane Database of Systematic Reviews - July 22, 2021 Category: General Medicine Authors: Vassiliki Sinopoulou Morris Gordon Terence M Dovey Anthony K Akobeng Source Type: research