Cancers, Vol. 13, Pages 3678: Follicular Helper T Cells Remodel the Immune Microenvironment of Pancreatic Cancer via Secreting CXCL13 and IL-21 (Stage-1)

Cancers, Vol. 13, Pages 3678: Follicular Helper T Cells Remodel the Immune Microenvironment of Pancreatic Cancer via Secreting CXCL13 and IL-21 (Stage-1) Cancers doi: 10.3390/cancers13153678 Authors: Xuan Lin Longyun Ye Xu Wang Zhenyu Liao Jia Dong Ying Yang Rulin Zhang Hao Li Pengcheng Li Lei Ding Tianjiao Li Wuhu Zhang Shuaishuai Xu Xuan Han Huaxiang Xu Wenquan Wang Heli Gao Xianjun Yu Liang Liu Immunosuppression is an important factor for the poor prognosis of pancreatic ductal adenocarcinoma (PDAC). Follicular helper T cells (Tfh cells) play an anti-tumor role in various malignant solid tumors and predict better patient prognosis. In the present study, we aimed to determine the immunosuppressive mechanism associated with Tfh cells and explore a new strategy to improve the tumor microenvironment of PDAC. Flow cytometry was used to detect the infiltration and proportion of Tfh cells in tumor tissues and peripheral blood from patients with PDAC. The spatial correlations of Tfh cells with related immune cells were evaluated using immunofluorescence. The function of Tfh cells was examined using in vitro and in vivo model systems. The high infiltration of Tfh cells predicted better prognosis in patients with PDAC. Tfh cells recruited CD8+ T cells and B cells by secreting C-X-C motif chemokine ligand 13 (CXCL13), and promoted the maturation of B cells into antibody-producing plasma cells by secreting interleukin 21 (IL-21), thereby pro...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Article Source Type: research