Integration of quantitative imaging biomarkers in clinical trials for MR-guided radiotherapy: Conceptual guidance for multicentre studies from the MR-Linac Consortium Imaging Biomarker Working Group

Quantitative imaging biomarkers (QIBs) derived from MRI techniques have the potential to be used for the personalised treatment of cancer patients. However, large-scale data are missing to validate their added value in clinical practice. Integrated MRI-guided radiotherapy (MRIgRT) systems, such as hybrid MRI-linear accelerators, have the unique advantage that MR images can be acquired during every treatment session. This means that high-frequency imaging of QIBs becomes feasible with reduced patient burden, logistical challenges, and costs compared to extra scan sessions.

Source: European Journal of Cancer - June 15, 2021 Category: Cancer & Oncology Authors: Petra J. van Houdt, Hina Saeed, Daniela Thorwarth, Clifton D. Fuller, William A. Hall, Brigid A. McDonald, Amita Shukla-Dave, Ernst S. Kooreman, Marielle E.P. Philippens, Astrid L.H.M.W. van Lier, Rick Keesman, Faisal Mahmood, Catherine Coolens, Teodor St Tags: Current Perspective Source Type: research