[Research Articles] Erythropoietin promotes abdominal aortic aneurysms in mice through angiogenesis and inflammatory infiltration

In conclusion, we found that EPO promotes the formation of AAA in both Apoe–/– and WT mice by enhancing angiogenesis, inflammation, collagen degradation, and apoptosis of SMCs and that EPO/EPOR signaling is essential for AngII-induced AAA. The association between EPO and AAA in humans warrants further study.

Source: Science Translational Medicine - July 21, 2021 Category: Biomedical Science Authors: Zhang, M., Sui, W., Cheng, C., Xue, F., Tian, Z., Cheng, J., Zhang, J., Zhang, T., Zhang, J., Wang, W., Xiong, W., Hao, P., Ma, J., Xu, X., Wang, S., Sun, S., Zhang, M., Zhang, Y., Zhang, C. Tags: Research Articles Source Type: research