Progressive Scleral Thinning in a Middle-aged Woman

A 50-year-old woman presents with left eye redness and headaches. Her best-corrected visual acuity is 20/20 OD and 20/25 OS. On examination, her left eye has 2 temporal scleral nodules with surrounding hyperemia and no scleromalacia. Laboratory test results show elevated levels of rheumatoid factor and C-reactive protein, and Lyme IgG, IgM, and reflex Western blot assays are positive for antibodies. Further testing shows she is negative for rheumatoid arthritis-associated nodular scleritis; however, new scleral thinning with persistence of the scleral nodules is noted. What would you do next?
Source: JAMA Ophthalmology - Category: Opthalmology Source Type: research

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AbstractBackgroundThe data on long-term outcome in enthesitis-related arthritis (ERA), the commonest category of JIA in India, is scant. Thus, we studied outcomes of ERA in a resource-constrained setting.MethodsPatients with ERA (ILAR classification) ( ≥ 5 years of disease and ≥ 18 years) were included. Data on clinical features, Bath indices (BASMI, BASDAI, BASFI), ASDAS, and health assessment questionnaire-disability index (HAQ-DI) was collected. X-ray pelvis including hips was obtained and compared with baseline X-ray for progressio n of sacroiliitis and hip arthritis. Fulfillment of...
Source: Clinical Rheumatology - Category: Rheumatology Source Type: research
AbstractPsoriatic arthritis (PsA) is a highly heterogenous disease, with many different clinical manifestations inside or outside of the musculoskeletal system and the skin. It is often accompanied by comorbidities like cardiovascular diseases and mental health disorders. Acute phase reactants are not always elevated and specific markers for diagnosis and/or monitor the disease are lacking thus far. These characteristics possibly reflect the difficulty in agreement about a disease activity index for PsA. Many indices have been proposed over the last years, each of them considering different combinations of disease characte...
Source: Clinical Rheumatology - Category: Rheumatology Source Type: research
ConclusionsRA and AS in people without clinically apparent heart disease are associated with the occurrence of adverse changes in CMR.Key Points•RA and AS in people without clinically apparent heart disease are associated with the occurrence of adverse changes in CMR..•The independent risk factors for higher LVEF are AS occurrence, human B27 leukocyte antigen occurrence, higher NGAL concentration and higher BMI..•RA presence, methotrexate use, higher RF, higher NGAL, older age and higher BMI are independent risk factors for higher LV T2 ratio..•RA occurrence, AS occurrence, type 2 diabetes occurrence an...
Source: Clinical Rheumatology - Category: Rheumatology Source Type: research
Rehabilitation (Stuttg). 2021 Oct;60(5):339-354. doi: 10.1055/a-1275-2657. Epub 2021 Oct 15.NO ABSTRACTPMID:34655068 | DOI:10.1055/a-1275-2657
Source: Die Rehabilitation - Category: Rehabilitation Authors: Source Type: research
CONCLUSIONS: Thus, the results of this study revealed that the fungal mediated AgONPs can be exploited as potential in biomedical applications.PMID:34655404 | DOI:10.1007/s11033-021-06824-w
Source: Molecular Biology Reports - Category: Molecular Biology Authors: Source Type: research
J Rheumatol. 2021 Oct 15:jrheum.210953. doi: 10.3899/jrheum.210953. Online ahead of print.ABSTRACTWe agree strongly with Kremer et al that "metrics are essential for evaluating disease activity in patients with rheumatoid arthritis (RA)."1 Nonetheless, data reported from the Corrona and the Brigham and Women's Rheumatoid Arthritis Sequential Study (BRASS) registries for Clinical Disease Activity Index (CDAI) and Routine Assessment of Patient Index Data 3 (RAPID3) are quite similar to those reported in the initial 2008 RAPID3 report.2.PMID:34654734 | DOI:10.3899/jrheum.210953
Source: J Rheumatol - Category: Rheumatology Authors: Source Type: research
CONCLUSION: Acute/chronic sinusitis and pharyngitis and acute respiratory burden increased RA risk. The mucosal paradigm of RA pathogenesis may involve the upper respiratory tract.PMID:34654732 | DOI:10.3899/jrheum.210580
Source: J Rheumatol - Category: Rheumatology Authors: Source Type: research
Coronavirus testing prices vary widely and can reach into the hundreds of dollars, making it hard for some travelers to budget for the added expense.
Source: NYT Health - Category: Consumer Health News Authors: Tags: Tests (Medical) Coronavirus (2019-nCoV) Travel and Vacations Budget Travel Prices (Fares, Fees and Rates) Content Type: Service Source Type: news
Fibroblasts are important cells for the support of homeostatic tissue function. In inflammatory diseases such as rheumatoid arthritis and inflammatory bowel disease, fibroblasts take on different roles (a) as inflammatory cells themselves and (b) in recruiting leukocytes, driving angiogenesis, and enabling chronic inflammation in tissues. Recent advances in single-cell profiling techniques have transformed the ability to examine fibroblast states and populations in inflamed tissues, providing evidence of previously underappreciated heterogeneity and disease-associated fibroblast populations. These studies challenge the pre...
Source: Journal of Clinical Investigation - Category: Biomedical Science Authors: Source Type: research
AbstractRetinitis pigmentosa (RP) is a blinding eye disease affecting nearly two million people worldwide. Dogs are affected with a similar illness termed progressive retinal atrophy (PRA). Lapponian herders (LHs) are affected with several types of inherited retinal dystrophies, and variants inPRCD andBEST1 genes have been associated with generalized PRA and canine multifocal retinopathy 3 (cmr3), respectively. However, all retinal dystrophy cases in LHs are not explained by these variants, indicating additional genetic causes of disease in the breed. We collected DNA samples from 10 PRA affected LHs, with knownPRCD andBES...
Source: Human Genetics - Category: Genetics & Stem Cells Source Type: research
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