Comparison of metolazone versus chlorothiazide in acute decompensated heart failure with diuretic resistance

ConclusionSequential nephron blockade with either metolazone or chlorothiazide appears to be efficacious and safe in ADHF, renal dysfunction, and diuretic resistance. Given the considerable cost difference favoring oral metolazone, larger randomized studies are warranted to confirm our findings and to exclude the possibility of confounding by indication.This article is protected by copyright. All rights reserved.

http://onlinelibrary.wiley.com/resolve/doi?DOI=10.1111%2F1755-5922.12109

Source: Cardiovascular Therapeutics - February 1, 2015 Category: Cardiology Authors: Michael Moranville, Suji Choi, Jennifer Hogg, Allen Anderson, Jonathan Rich Tags: Original Research Article Source Type: research