Fabrication of gelatin microspheres containing ammonium hydrogen carbonate for the tunable release of herbicide

In this study, gelatin microspheres were prepared by emulsion and cross-linking, then they were loaded with 2,4-dichlorophenoxyacetic acid sodium (2,4-D Na) as a model herbicide. To achieve temperature-tunable release of 2,4-D Na from the microspheres, NH4HCO3 was added to the formulations at different concentrations. The prepared formulations were characterized by SEM, FTIR, and size distribution analyzes, and their drug loading capacities were determined. Based on bioassay experiments, the 2,4-D Na-NH4HCO3-loaded gelatin microspheres can effectively control the spread of dicotyledonous weeds. Therefore, the strategy proposed herein can be used to develop novel, effective herbicide formulations.PMID:34275026 | DOI:10.1007/s10529-021-03163-5

Source: Biotechnology Letters - July 18, 2021 Category: Biotechnology Authors: He Liu Zheng Zhang Jiaxin Li Wanyu Zang Qing Yang Jun Yang Source Type: research