NANOG gene suppression and replacement of let-7 modulate the stemness, invasion, and apoptosis in breast cancer

In conclusion, these findings showed that a combination of Let-7a miRNA mimic and Nanog siRNA could be exploited as a new treatment to enhance tumoricidal strategy treatment and to improve the cancer therapy outcome. In this study, we showed that the using a combination of Let-7a increase and NANOG inhibition could possibly tumoricidal outcome.PMID:34274471 | DOI:10.1016/j.gene.2021.145844

Source: Gene - July 18, 2021 Category: Genetics & Stem Cells Authors: Zeynab Aliyari Serej Ayyub Ebrahimi Tohid Kazemi Souzan Najafi Mohammad Amini Parastou Nastarin Elham Baghbani Behzad Baradaran Source Type: research