Peptides With Laminin Activity

Technology IDE-521-1986-3 Peptides With Laminin ActivityLinked IDTAB-95InventorsFrank Robey (NIDCR)George Martin (NIDCR)Hynda Kleinman (NIDCR)Jeannette Graf ()Makoto Sasaki ()Yoshihiko Yamada (NIDCR)Yukihide Iwamoto ()Lead InventorsYoshihiko Yamada (NIDCR)Co-InventorsFrank Robey (NIDCR)George Martin (NIDCR)Hynda Kleinman (NIDCR)Jeannette Graf ()Makoto Sasaki ()Yukihide Iwamoto ()Development StagesPre-clinical (in vivo)ICsNIDCRCommercial Applicationscancer therapeuticresearch reagentPeptides with laminin activity, including YIGSR, are claimed. These peptides block angiogenesis, alter the formation of capillary structures by endothelial cells, prevent the formation of excess blood vessels in tissue and inhibit in vivo tumor cell colonization of tissues. These peptides can be used, among other things, to inhibit metastasis. {RefNo is 95 }Competitive Advantagesencourage cell adhesioninhibits metastasis and angiogenesisRequest More InfoLicensing ContactVladimir Knezevic, M.D.vlado.knezevic@nih.govPhone: 301.443.5560Related InventionsLAMININ A CHAIN DEDUCED AMINO ACID SEQUENCE, EXPRESSION VECTORS AND ACTIVE SYNTHETIC PEPTIDES [E-246-1988-0]Intellectual PropertiesUS Pat5,092,885Issued 1992-03-03PublicationsJ Graf, Y Iwamoto, M Sasaki, GR Martin, HK Kleinman, FA Robey, Y Yamada. Identification of an amino acid sequence in laminin mediating cell attachment, chemotaxis, and receptor binding. Cell 1987 Mar 27;48(6):989-9.K Yamamura, MC Kibbey, SH Jun, HK Kleinman. Effect of Matrigel an...
Source: NIH OTT Licensing Opportunities - Category: Research Authors: Source Type: research