Evaluation and categorisation of individual patients based on white matter profiles: Single-patient diffusion data interpretation in neurodegeneration

The majority of radiology studies in neurodegenerative conditions infer group-level imaging traits from group comparisons. While this strategy is helpful to define phenotype-specific imaging signatures for academic use, the meaningful interpretation of single scans from individual subjects is more important in everyday clinical practice. Accordingly, we present a computational method to evaluate individual subject diffusion tensor data to highlight white matter integrity alterations. Fifty white matter (WM) tracts were quantitatively rated in 132 ALS patients separately with respect to demographically-matched normative values from 100 healthy subjects.
Source: Journal of the Neurological Sciences - Category: Neurology Authors: Source Type: research