Hyperbaric Oxygen Therapy Represses the Warburg Effect and Epithelial –Mesenchymal Transition in Hypoxic NSCLC Cells via the HIF-1α/PFKP Axis

ConclusionsHBO’s repression of the Warburg effect, repression of hyperproliferation, and repression of EMT in hypoxic NSCLC cells is dependent upon HIF-1α downregulation. HIF-1α’s target gene PFKP functions as a central mediator of HBO’s effects in hypoxic NSCLC cells and may represent a metabolic vulnerability in NSCLC tumors.
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research