Progression in Moyamoya Disease: Clinical Feature, Neuroimaging Evaluation and Treatment

Curr Neuropharmacol. 2021 Jul 15. doi: 10.2174/1570159X19666210716114016. Online ahead of print.ABSTRACTMoyamoya disease (MMD) is a chronic cerebrovascular disease characterized by progressive stenosis of the arteries of the circle of Willis, with the formation of the collateral vascular network at the base of the brain. Its clinical manifestations are complicated. Numerous studies have attempted to clarify the clinical features of MMD, including its epidemiology, genetic characteristics, and pathophysiology. With the development of neuroimaging techniques, various neuroimaging modalities with different advantages have deepened the understanding of MMD in structural, functional, spatial, and temporal dimensions. At present, the main treatment for MMD focuses on neurological protection, cerebral blood flow reconstruction, and neurological rehabilitation, such as pharmacological treatment, surgical revascularization, and cognitive rehabilitation. In this review, we discuss recent progress in understanding the clinical features, neuroimaging evaluation, and treatment of MMD.PMID:34279201 | DOI:10.2174/1570159X19666210716114016
Source: Current Neuropharmacology - Category: Drugs & Pharmacology Authors: Source Type: research