MicroRNA 452 regulates IL20RA-mediated JAK1/STAT3 pathway in inflammatory colitis and colorectal cancer

ConclusionOur results suggest thatMIR452 regulates STAT3 through the IL20RA-mediated JAK1 pathway, but not STAT1. Overall,MIR452 acts as tumor suppressor in human CRC and in a mouse colitis model. These findings suggest thatMIR452 is a promising therapeutic target in the treatment of cancer and colitis.

http://link.springer.com/10.1007/s00011-021-01486-7

Source: Inflammation Research - July 20, 2021 Category: Research Source Type: research