Recent Trend: Melanoma Mortality Declining Rapidly Recent Trend: Melanoma Mortality Declining Rapidly

The drop in death rates has occurred despite increased incidence rates for both men and women.Medscape Medical News
Source: Medscape Medical News Headlines - Category: Consumer Health News Tags: Dermatology News Source Type: news

Related Links:

We present a case of a 38-year-old man with Fitzpatrick skin type IV with an asymmetric black papule showing clinical and dermoscopic features of both melanoma and SK. Reflectance confocal microscopy (RCM) and dynamic optical coherence tomography (d-OCT) were used for further evaluation. RCM revealed acanthotic epidermis with a mixed honeycomb and cobblestone pattern, polycyclic bulbous rete ridges, and bright plump cells within entrapped, edged, dermal papillae, compatible with pigmented SK. Also noted were a population of fairly uniform bright dendritic cells scattered quite evenly at all levels of the epidermis and the ...
Source: The American Journal of Dermatopathology - Category: Pathology Tags: Extraordinary Case Report Source Type: research
Cancer Immunol Res. 2021 Sep 24:canimm.0094.2021. doi: 10.1158/2326-6066.CIR-21-0094. Online ahead of print.ABSTRACTDendritic cells (DCs), the classical antigen-presenting cells of the immune system, switch from an adhesive, phagocytic phenotype in tissues, to a mature, non-adhesive phenotype that enables migration to lymph nodes to activate T cells and initiate antitumor responses. Monocyte-derived DCs are used in cancer immunotherapy but their clinical efficacy is limited. Here, we show that cultured bone marrow-derived DCs (BM-DCs) expressing dysfunctional β2-integrin adhesion receptors displayed enhanced tumor rej...
Source: Cell Research - Category: Cytology Authors: Source Type: research
The National Cancer Institute (NCI) awarded Penn Medicine and The Wistar Institute $11.7 million to support melanoma research. The five-year award from the NCI's Specialized Programs of Research Excellence will be used to fund three new melanoma research projects. The projects will seek to translate laboratory discoveries made in the Perelman School of Medicine at the University of Pennsylvania and at The Wistar Institu te, both in West Philadelphia, into new therapeutics to treat skins cancers. Melanoma…
Source: bizjournals.com Health Care:Physician Practices headlines - Category: American Health Authors: Source Type: news
This article reviews the abnormal expression of miR-802 in a variety of tumors, expounds the mechanism by which miR-802 affects tumor progression by regulating different target genes, and elaborates the network of miR-802-related ceRNAs. We also summarized the limitations of miR-802 research and looked forward to the potential application of miR-802 in the diagnosis and prognosis of tumors.PMID:34558723 | DOI:10.1002/jcla.23989
Source: Clinical Lung Cancer - Category: Cancer & Oncology Authors: Source Type: research
Diagn Interv Radiol. 2021 Sep;27(5):684-689. doi: 10.5152/dir.2021.20503.ABSTRACTHigh-dose interleukin-2 (HDIL-2) therapy was initially approved by the U.S. Food and Drug Administration for metastatic renal cell carcinoma (mRCC) and metastatic melanoma. IL-2 is able to promote CD8+ T cell and natural killer (NK) cell cytotoxicity to increase tumoricidal activity of the innate immune system. HDIL-2 therapy is associated with a wide spectrum of immune-related adverse events (irAEs) that can be radiologically identified. HDIL-2 toxicity can manifest in multiple organ systems, most significantly leading to cardiovascular, abdo...
Source: Diagnostic and Interventional Radiology - Category: Radiology Authors: Source Type: research
This article reviews the abnormal expression of miR-802 in a variety of tumors, expounds the mechanism by which miR-802 affects tumor progression by regulating different target genes, and elaborates the network of miR-802-related ceRNAs. We also summarized the limitations of miR-802 research and looked forward to the potential application of miR-802 in the diagnosis and prognosis of tumors.PMID:34558723 | DOI:10.1002/jcla.23989
Source: Clinical Genitourinary Cancer - Category: Cancer & Oncology Authors: Source Type: research
Conclusions. ICG dye lymphangiography is a good alternative for locating SLNs in patients with melanoma. It could also visualize well perfusion skin paddle during reconstruction. We reported a reproducible and simple method to utilize ICG fluorescence in cutaneous melanoma patients.PMID:34555944 | DOI:10.1177/15533506211020226
Source: Surgical Innovation - Category: Surgery Authors: Source Type: research
Pharmacol Res. 2021 Sep 21:105911. doi: 10.1016/j.phrs.2021.105911. Online ahead of print.ABSTRACTIn melanomas, therapy resistance can arise due to a combination of genetic, epigenetic and phenotypic mechanisms. Due to its crucial role in DNA supercoil relaxation, TOP1 is often considered an essential chemotherapeutic target in cancer. However, how TOP1 expression and activity might differ in therapy sensitive versus resistant cell types is unknown. Here we show that TOP1 expression is increased in metastatic melanoma and correlates with an invasive gene expression signature. More specifically, TOP1 expression is highest i...
Source: Cell Research - Category: Cytology Authors: Source Type: research
This article reviews the abnormal expression of miR-802 in a variety of tumors, expounds the mechanism by which miR-802 affects tumor progression by regulating different target genes, and elaborates the network of miR-802-related ceRNAs. We also summarized the limitations of miR-802 research and looked forward to the potential application of miR-802 in the diagnosis and prognosis of tumors.PMID:34558723 | DOI:10.1002/jcla.23989
Source: Clinical Breast Cancer - Category: Cancer & Oncology Authors: Source Type: research
Diagn Interv Radiol. 2021 Sep;27(5):684-689. doi: 10.5152/dir.2021.20503.ABSTRACTHigh-dose interleukin-2 (HDIL-2) therapy was initially approved by the U.S. Food and Drug Administration for metastatic renal cell carcinoma (mRCC) and metastatic melanoma. IL-2 is able to promote CD8+ T cell and natural killer (NK) cell cytotoxicity to increase tumoricidal activity of the innate immune system. HDIL-2 therapy is associated with a wide spectrum of immune-related adverse events (irAEs) that can be radiologically identified. HDIL-2 toxicity can manifest in multiple organ systems, most significantly leading to cardiovascular, abdo...
Source: Diagnostic and Interventional Radiology : The Turkish Society of Radiology - Category: Radiology Authors: Source Type: research
More News: Dermatology | Health | Melanoma | Skin | Skin Cancer | Women