SQSTM1/p62 droplet -mediated autophagosome formation:insights into Huntington disease

Autophagy. 2021 Jul 19:1-4. doi: 10.1080/15548627.2021.1953820. Online ahead of print.ABSTRACTHuntington disease (HD) manifests a unique macroautophagy/autophagy defect: the presense of cytosolic autophagosomes without substrates or so-called "empty" autophagosomes. It was proposed that mutant HTT (huntingtin; mHTT) disrupts cargo recognition by the selective autophagy receptor SQSTM1/p62 thus leading to the failure of cargo sequestration by phagophores, the precursors to autophagosomes. Here we looked at recent discoveries that liquid-like SQSTM1 droplets can serve as platforms for autophagosome formation, and discussed possible alternative mechanisms for "empty" autophagosome formation in HD inspired by these findings.PMID:34281469 | DOI:10.1080/15548627.2021.1953820

Source: Autophagy - July 20, 2021 Category: Cytology Authors: Junsheng Yang Xiaoli Chen Huilin Xu Source Type: research