CaMKII inhibition has dual effects on spontaneous Ca < sup > 2+ < /sup > release and Ca < sup > 2+ < /sup > alternans in ventricular cardiomyocytes from mice with a gain-of-function RyR2 mutation

CONCLUSIONS: Inhibition of CaMKII efficiently reduces spontaneous Ca2+-release, but promotes Ca2+ alternans in RyR2-R2474S cardiomyocytes with a gain-of-function RyR2 mutation. The dominant effect in RyR2-R2474S is to reduce spontaneous Ca2+-release, which supports this intervention as a therapeutic strategy in this specific condition. However, future studies on CaMKII inhibition in conditions with increased propensity for Ca2+ alternans should include investigation of both phenomena.PMID:34270372 | DOI:10.1152/ajpheart.00011.2021
Source: American Journal of Physiology. Heart and Circulatory Physiology - Category: Physiology Authors: Source Type: research