Ruyiping extract reduces lung metastasis in triple negative breast cancer by regulating macrophage polarization

This study was to explore the anti-lung-metastatic activities and mechanism of RYP extract by regulating macrophage polarization. The results showed that RYP can inhibit the viability and induce the apoptosis of TNBC cells. In in vitro experiments, RYP significantly inhibited the invasion and migration ability of TNBC cells promoted by M2, the subtype of macrophage which increased TNBC metastasis related genes. In in vivo experiments, RYP reduced the TNBC progression and lung metastasis. M2/M1 ration in the lung and M2 in the tumor was reduced by RYP, as well as M2 master regulator Stat6. Therefore, RYP extract may exhibit anti-lung metastasis function by reducing M2 in both tumor and lung through reducing Stat6.PMID:34246955 | DOI:10.1016/j.biopha.2021.111883

Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - July 11, 2021 Category: Drugs & Pharmacology Authors: Rui Yang Ying Xie Qiong Li Yiyi Ye Youyang Shi Xiangdong Zhao Chunyu Wu Yiyun Xu Rui Wang Yang Zhang Xiaojuan Yang Xianghui Han Sheng Liu Source Type: research