Advanced cardiovascular multimodal imaging and aortic stenosis

AbstractAortic valve stenosis has become the most common valvular heart disease on account of  aging population and increasing life expectancy. Echocardiography is the primary diagnosis tool for this, but it still has many flaws. Therefore, advanced cardiovascular multimodal imaging techniques are continuously being developed in order to overcome these limitations. Cardiac magnetic resonan ce imaging (CMR) allows a comprehensive morphological and functional evaluation of the aortic valve and provides important data for the diagnosis and risk stratification in patients with aortic stenosis. CMR can functionally assess the aortic flow using two-dimensional and time-resolved three-di mensional velocity-encoded phase-contrast techniques. Furthermore, by late gadolinium enhancement and T1-mapping, CMR can reveal the presence of both irreversible replacement and diffuse interstitial myocardial fibrosis. Moreover, its role in guiding aortic valve replacement procedures is beginning to take shape. Recent studies have rendered the importance of active and passive biomechanics in risk stratification and prognosis prediction in patients with aortic stenosis, but more work is required is just in its infancy, but data are promising. In addition, cardiac computed tomography is partic ularly useful for the diagnosis of aortic valve stenosis, and in preprocedural evaluation of the aorta, while positron emission tomography can be also used to assess valvular inflammation a...
Source: Heart Failure Reviews - Category: Cardiology Source Type: research

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Circ Res. 2021 Apr 30;128(9):1371-1397. doi: 10.1161/CIRCRESAHA.120.317979. Epub 2021 Apr 29.ABSTRACTCalcific aortic valve disease sits at the confluence of multiple world-wide epidemics of aging, obesity, diabetes, and renal dysfunction, and its prevalence is expected to nearly triple over the next 3 decades. This is of particularly dire clinical relevance, as calcific aortic valve disease can progress rapidly to aortic stenosis, heart failure, and eventually premature death. Unlike in atherosclerosis, and despite the heavy clinical toll, to date, no pharmacotherapy has proven effective to halt calcific aortic valve disea...
Source: Circulation Research - Category: Cardiology Authors: Source Type: research
egnite, a digital healthcare company based in California, offers the CardioCare, an AI-based solution that aims to help clinicians identify and treat patients with structural heart disease. CardioCare is already used in over 50 hospitals in the US. ...
Source: Medgadget - Category: Medical Devices Authors: Tags: Cardiology Exclusive Source Type: blogs
CONCLUSIONS Mitral valve disease (regurgitation and stenosis) was significantly correlated with systolic dysfunction, whereas aortic and mitral regurgitation were associated with diastolic dysfunction. Better monitoring of cardiovascular disease risk factors may lead to a reduced burden of LVD and VHD. PMID: 33558450 [PubMed - in process]
Source: Medical Science Monitor - Category: Research Tags: Med Sci Monit Source Type: research
AbstractIn patients with significant aortic stenosis (AS), the prognostic effect of the increase in left ventricular mass (LVM) in relation to one ’s hemodynamic load has been described. Inappropriately high LVM has been shown to predict adverse cardiovascular events. However, little is known about the prognostic impact of inadequately low LVM (i-lowLVM) in patients with significant AS. I-lowLVM was defined as the measured LVM 
Source: The International Journal of Cardiovascular Imaging - Category: Radiology Source Type: research
Congenital heart disease (CHD) is a lifelong condition and appropriate follow-up in expert hands is a key to achieving a good long-term outcome by recognizing and addressing the specific and highly variable complications timely. All adult congenital heart disease (ACHD) patients should be seen once in a specialist centre, allowing ACHD specialists to determine the most appropriate level of care —exclusive care in a specialist centre, shared care between the centre and general adult cardiac services, or care in non-specialist cardiology clinics with access to specialized care when required—as well as adequate fo...
Source: European Heart Journal - Category: Cardiology Source Type: research
Discussion Congenital heart diseases (CHD) are malformations of the heart and great vessels. It occurs in about 5-8/1000 live births. Cyanotic congenital heart disease is often noted perinatally because of cyanosis, respiratory distress and/or poor feeding or other distress type problems. A review can be found here. Acyanotic congenital heart disease (ACHD) can present at birth but often is seen in older children or adults unless the lesions are severe, especially obstructive lesions. Severe lesions may also cause cyanosis and distress type problems in patients also. Shunting lesions cause problems by diverting blood flo...
Source: PediatricEducation.org - Category: Pediatrics Authors: Tags: Uncategorized Source Type: news
AbstractObjectivesTo evaluate how pulmonary artery (PA) distensibility performs in detecting pulmonary hypertension due to left heart disease (PH-LHD) in comparison with parameters from ungated computed tomography (CT) and echocardiography.MethodsOne hundred patients (79 men, mean age  = 63 ± 17 years) with either severe heart failure with reduced ejection fraction (HFrEF), aortic stenosis, or primary mitral regurgitation prospectively underwent right heart catheterization, ungated CT, ECG-gated CT, and echocardiography. During the ECG-gated CT, the right PA distensibil ity was calcu...
Source: European Radiology - Category: Radiology Source Type: research
Cardiac scintigraphy with 99mTc pyrophosphate (PYP) has a high diagnostic accuracy for transthyretin (ATTR) cardiac amyloidosis (CA) and is being increasingly used to diagnose this condition noninvasively.1-3 Multisocietal guidelines recommend performing 99mTc PYP scintigraphy in patients with heart failure and left ventricular (LV) hypertrophy on transthoracic echocardiography (TTE).1,2 Other features on TTE (increased interatrial septal thickness, pericardial effusion, and biatrial enlargement) and electrocardiography (low voltage, conduction abnormalities, and a pseudo-infarct pattern) may increase the suspicion for CA ...
Source: Journal of the American Society of Echocardiography - Category: Cardiology Authors: Tags: Letters to the Editor Source Type: research
AbstractHeart failure with reduced ejection fraction (HFrEF) is common in patients with adult congenital heart disease. Many of the most common congenital defects have a high prevalence of HFrEF, including left-sided obstructive lesions (aortic stenosis, coarctation of the aorta, Shone complex), tetralogy of Fallot, Ebstein anomaly, lesions in which there is a systemic right ventricle, and lesions palliated with a Fontan circulation. However, heart failure with preserved ejection fraction (HFpEF) is also prevalent in all these lesions. Comprehensive evaluation includes physical exam, biomarkers, echocardiography and advanc...
Source: Heart Failure Reviews - Category: Cardiology Source Type: research
Publication date: Available online 21 November 2019Source: Canadian Journal of CardiologyAuthor(s): Gabriele Crimi, Claudio Montalto, Luca Angelo Ferri, Luigi Piatti, Irene Bossi, Nuccia Morici, Alessandro Mandurino-Mirizzi, Daniele Grosseto, Giovanni Tortorella, Stefano Savonitto, Stefano De Servi, Elderly-ACS 2 InvestigatorsABSTRACTBackgroundElderlies are underrepresented in clinical trials and registries and a gap of evidence exists for clinical decision making in the setting of acute coronary syndromes (ACS). We aimed to assess the prevalence and independent prognostic impact of valvular heart disease (VHD) diagnosed d...
Source: Canadian Journal of Cardiology - Category: Cardiology Source Type: research
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