AMPA receptor trafficking and LTP: Carboxy-termini, amino-termini and TARPs

Neuropharmacology. 2021 Jul 13:108710. doi: 10.1016/j.neuropharm.2021.108710. Online ahead of print.ABSTRACTAMPA receptors (AMPARs) are fundamental elements in excitatory synaptic transmission and synaptic plasticity in the CNS. Long term potentiation (LTP), a form of synaptic plasticity which contributes to learning and memory formation, relies on the accumulation of AMPARs at the postsynapse. This phenomenon requires the coordinated recruitment of different elements in the AMPAR complex. Based on recent research reviewed herein, we propose an updated AMPAR trafficking and LTP model which incorporates both extracellular as well as intracellular mechanisms.PMID:34271016 | DOI:10.1016/j.neuropharm.2021.108710
Source: Neuropharmacology - Category: Drugs & Pharmacology Authors: Source Type: research