The multi-faceted roles of TGF- β in regulation of immunity to infection

Adv Immunol. 2021;150:1-42. doi: 10.1016/bs.ai.2021.05.001. Epub 2021 Jun 4.ABSTRACTTransforming Growth Factor-β is a potent regulator of the immune system, acting at every stage from thymic differentiation, population of the periphery, control of responsiveness, tissue repair and generation of memory. It is therefore a central player in the immune response to infectious pathogens, but its contribution is often clouded by multiple roles acting on different cells in time and space. Hence, context is all-important in understanding when TGF-β is beneficial or detrimental to the outcome of infection. In this review, a full range of infectious agents from viruses to helminth parasites are explored within this framework, drawing contrasts and general conclusions about the importance of TGF-β in these diseases.PMID:34176558 | DOI:10.1016/bs.ai.2021.05.001
Source: Advances in Immunology - Category: Allergy & Immunology Authors: Source Type: research