Urine levels of the polyglutamine ataxin-3 protein are elevated in patients with spinocerebellar ataxia type 3
Accumulation of polyglutamine (polyQ) ataxin-3 (ATXN3) contributes to the pathobiology of spinocerebellar ataxia type 3 (SCA3). Recently, we showed that polyQ ATXN3 is elevated in the plasma and cerebrospinal fluid (CSF) of SCA3 patients, and has the potential to serve as a biological marker for this disease [1]. Based on these findings, we investigated whether polyQ ATXN3 can also be detected in urine samples from SCA3 patients.
Source: Parkinsonism and Related Disorders - Category: Neurology Authors: Yuka Koike, Karen R. Jansen-West, Rana Hanna AL-Shaikh, Yari Carlomagno, Yuping Song, Judith A. Dunmore, Mark S. LeDoux, Joseph H. Friedman, Ashley B. Pena, Ryan J. Uitti, Jacek Zaremba, Jay A. van Gerpen, Ronald F. Pfeiffer, Venka Veerappan, Ikuko Aiba, Tags: Short communication Source Type: research