Circulating IgA/IgG memory B cell against Mycobacterium tuberculosis dormancy-associated antigens Rv2659c and Rv3128c in active and latent tuberculosis

Tuberculosis (TB) caused by Mycobacterium tuberculosis (Mtb) is a major public health problem, listed in Sustainable Development Goal 3. There were an estimated 10 million new cases, as well as 1.2 million deaths, in 2019 (WHO, 2020). Importantly, latent infections are estimated to be present in a quarter of the global population (WHO, 2020). From this stage, approximately 5-10% of people progress to active TB during their lifetime. Thus, not only do latent tuberculosis individuals (LTBIs) become reservoirs of active TB, but they also stand as a key challenge for global TB control (Raviglione and Sulis, 2016).

Source: International Journal of Infectious Diseases - July 17, 2021 Category: Infectious Diseases Authors: Phyu Thwe Soe, Jariya Hanthamrongwit, Chutiphon Saelee, Soe Paing Kyaw, Prasong Khaenam, Saradee Warit, Nusara Satproedprai, Surakameth Mahasirimongkol, Hideki Yanai, Patchanee Chootong, Chaniya Leepiyasakulchai Source Type: research