Synthetic Attempts Towards Eminent Anti-Viral Candidates of SARS-CoV

Mini Rev Med Chem. 2021 Jul 12. doi: 10.2174/1389557521666210712205655. Online ahead of print.ABSTRACTSevere Acute Respiratory Syndrome (SARS) aka SARS-CoV spread over southern China for the first time in 2002-2003 and history repeated again since last year and take away more than two million people so far. On March 11, 2020 COVID-19 outbreak was officially declared as pandemic by World Health Organization (WHO). Entire world united to fight back against this ultimate destruction. Around 90 vaccines are featured against SARS-CoV-2 and more than 300 active clinical trials are underway by several groups and individuals. So far, no drugs are currently approved that completely eliminates the deadly corona virus. The promising SARS-CoV-2 anti-viral drugs are favipiravir, remdesivir, lopinavir, ribavirin and avifavir. In this review, we have discussed the synthetic approaches elaborately made so far by different groups and chemical companies all around the world towards top three convincing anti-viral drugs against SARS-CoV-2 which are favipiravir, remdesivir and lopinavir.PMID:34254915 | DOI:10.2174/1389557521666210712205655
Source: Mini Reviews in Medicinal Chemistry - Category: Chemistry Authors: Source Type: research