Review: Why permanent control of cassava Brown streak disease in sub Saharan Africa have remained a dream come true since 1930s?

Infect Genet Evol. 2021 Jul 13:105001. doi: 10.1016/j.meegid.2021.105001. Online ahead of print.ABSTRACTEffective control of causal Ipomoviruses of Brown Streak Disease of Cassava (CBSD) in Africa have remained problematic besides remarkable 8 decades (1930s-2021) of research efforts. Reasons underlying resistance breakdown in genetically improved Cassava and expansion of host-and-vector range of Cassava Brown Streak Viruses are still unknown. Enormous genetic diversity of Cassava Brown Streak Viruses which is crucial for improving routine Reverse Transcription Polymerase Chain Reaction in CBSD-endemic regions of Africa is controversial and under-represented. From molecular epidemiology viewpoint, this review discusses why CBSD have remained hard to control permanently in modern era full of diverse in silico and Omics tools, recombinant DNA and High Through-put Next Generation Sequencing technologies. Following an extensive literature and nucleotide data search in National Institute of Biotechnology Virus resource and PUBMED correspondingly, we report that genomic data of 474 (87.62%) of prevailing 541 strains of CBSVs is missing due to poor sequencing capacity in Africa. Knowledge on evolution dynamics of viral virulence and pathogenicity isn't yet harnessed fully from available 67(12.38%) genomic sequence data owing to poor bioinformatics capacity. Tanzania is the most affected country with highest disease inoculum pressure (158 CBSV and 14 UCBSV) followed by Uganda (74 CBS...
Source: Infection, Genetics and Evolution - Category: Genetics & Stem Cells Authors: Source Type: research