Does a strict glycemic control during acute coronary syndrome play a cardioprotective effect? Pathophysiology and clinical evidence

A hyperglycemic state, also in non-diabetic subjects, may be associated with acute coronary syndrome (ACS). Aim of this review is to describe the pathophysiologic association between ACS and hyperglycemic state, the protective mechanisms of a tight glycaemic control in ACS on CV outcomes, and the supporting clinical evidence. Several mechanisms may be responsible of a poor CV outcome in subjects with hyperglycemia during ACS. Endothelial NAPDH oxidase-2 (NOX2) activation in response to high glucose alters the balance between Raf/MAPK-dependent vasoconstriction and PI3K/Akt-dependent vasodilation in favour of constriction.

Source: Diabetes Research and Clinical Practice - July 16, 2021 Category: Endocrinology Authors: Alfredo Caturano, Raffaele Galiero, Pia Clara Pafundi, Arturo Cesaro, Erica Vetrano, Giuseppe Palmiero, Luca Rinaldi, Teresa Salvatore, Elisabetta Moscarella, Felice Gragnano, Paolo Calabr ò, Ferdinando Carlo Sasso Tags: Review Source Type: research