Exploring CNS effects of American traditional medicines using zebrafish models

Curr Neuropharmacol. 2021 Jul 12. doi: 10.2174/1570159X19666210712153329. Online ahead of print.ABSTRACTAlthough American traditional medicine (ATM) has been practiced for millennia, its complex multi-target mechanisms of therapeutic action remain poorly understood. Animal models are widely used to elucidate the therapeutic effects of various ATMs, including their modulation of brain and behavior. Complementing rodent models, the zebrafish (Danio rerio) is a promising novel organism in translational neuroscience and neuropharmacology research. Here, we emphasize the growing value of zebrafish for testing neurotropic effects of ATMs and outline future directions of research in this field. We also demonstrate the developing utility of zebrafish as complementary models for probing CNS mechanisms of ATM action and their potential to treat brain disorders.PMID:34254921 | DOI:10.2174/1570159X19666210712153329
Source: Current Neuropharmacology - Category: Drugs & Pharmacology Authors: Source Type: research