Loss of FANCD2 and related proteins may predict malignant transformation in oral epithelial dysplasia

Predicting malignant transformation in oral epithelial dysplasia(OED) is challenging. The higher rate of malignant transformation (MT) reported in non-smokers suggests an endogenous etiology in oncogenesis. We hypothesize that loss of FANCD2 and associated proteins could influence genomic instability and MT in the absence of environmental carcinogens.

https://www.oooojournal.net/article/S2212-4403(21)00508-3/fulltext?rss=yes

Source: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics - July 16, 2021 Category: ENT & OMF Authors: Michael W Ho, Mark P Ryan, Juhi Gupta, Asterios Triantafyllou, Janet M Risk, Richard J Shaw, James B Wilson Source Type: research