Genetic risk for chronic pain is associated with lower antidepressant effectiveness: Converging evidence for a depression subtype

CONCLUSION: These results suggest genetic risk for chronic pain accounted for poorer antidepressant effectiveness, independent of the genetic risk for major depression. Our results, along with independent converging evidence from other studies, point towards a difficult-to-treat depression subtype characterised by comorbid chronic pain. This finding warrants further investigation into the implications for biologically based nosology frameworks in pain medicine and psychiatry.PMID:34266302 | DOI:10.1177/00048674211031491

Source: The Australian and New Zealand Journal of Psychiatry - July 16, 2021 Category: Psychiatry Authors: Adri án I Campos Trung Thanh Ngo Sarah E Medland Naomi R Wray Ian B Hickie Enda M Byrne Nicholas G Martin Miguel E Renter ía Source Type: research