Benralizumab Promising for Rhinosinusitis With Nasal Polyps Benralizumab Promising for Rhinosinusitis With Nasal Polyps

Benralizumab reduced both nasal polyp and nasal blockage scores significantly. This hard-to-treat disease with severe patient burden has few existing pharmacologic treatments.Medscape Medical News
Source: Medscape Medical News Headlines - Category: Consumer Health News Tags: Allergy & Clinical Immunology News Source Type: news

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To summarize the therapeutic effects and safety of biologics either approved or in clinical development for asthma, COPD, urticaria, nasal polyps, atopic dermatitis, and eosinophilic esophagitis. This review attempts to provide some guidance when choosing between agents.
Source: Annals of Allergy, Asthma and Immunology - Category: Allergy & Immunology Authors: Tags: Review Source Type: research
ConclusionsLYR-210 is the first implantable sinonasal treatment to achieve up to 24 weeks of benefit from a single administration in surgically naive CRS patients with and without nasal polyps.
Source: International Forum of Allergy and Rhinology - Category: Allergy & Immunology Authors: Tags: ORIGINAL ARTICLE Source Type: research
In this open-label extension study of POLYP 1/2, patients with severe CRSwNP with inadequate response to nasal corticosteroids who were treated with omalizumab experienced significant improvements in endoscopic, clinical, and patient-reported outcomes over 52 weeks.
Source: Journal of Allergy and Clinical Immunology - Category: Allergy & Immunology Authors: Source Type: research
AbstractBackgroundAir pollution directly interacts with airway mucosa, yet little is known about how pollutants affect upper airway inflammation. Studies have shown increased incidence of chronic rhinosinusitis (CRS), rhinitis, and asthma in areas with higher traffic pollution, and these neighborhoods are often associated with lower socioeconomic status (SES). The Area Deprivation Index (ADI) assesses neighborhood-level SES by zip code. The purpose of this study was to assess the relationship between SES and exposure to inhaled pollutants and CRS disease severity.MethodsCRS patients with and without nasal polyps (CRSwNP an...
Source: International Forum of Allergy and Rhinology - Category: Allergy & Immunology Authors: Tags: ORIGINAL ARTICLE Source Type: research
In this report, we present outcomes data collected over 5 years in a large prospective cohort of patients who underwent surgical treatment for CRS.MethodsPatients who completed the 22-item Sino-Nasal Outcome Test (SNOT-22) before ESS were asked to complete the same survey at yearly intervals for 5 years thereafter. The impact of patients ’ demographics and clinical characteristics on clinical outcome was measured using mixed effects modeling for univariate and multivariable analysis. Multivariable logistic regression threshold analyses were also performed.ResultsAmong the 925 patients enrolled in the study, the SNOT-...
Source: International Forum of Allergy and Rhinology - Category: Allergy & Immunology Authors: Tags: ORIGINAL ARTICLE Source Type: research
In this study, we examined SGK1 expression and its possible pathogenic roles in chronic rhinosinusitis (CRS).METHODS: Immunohistochemistry, western blotting, Bio-Plex assay, enzyme-linked immunosorbent assays, and quantitative real-time polymerase chain reaction were performed to assess protein and gene expression levels. The mRNA expression levels of SGK1 and interleukin-6 (IL-6) were extracted from a CRS database to perform correlation analysis. Stable cell lines with SGK1 overexpression (16HBE) and knockdown (A549) were constructed to investigate the interaction between SGK1 and IL-6 in vitro.RESULTS: SGK1 exhibited str...
Source: Allergy, Asthma and Immunology Research - Category: Allergy & Immunology Authors: Source Type: research
Allergy Asthma Immunol Res. 2021 Sep;13(5):684-696. doi: 10.4168/aair.2021.13.5.684.ABSTRACTArachidonic acid 15-lipoxygenase (ALOX15) is an enzyme that can oxidize polyunsaturated fatty acids. ALOX15 is strongly expressed in airway epithelial cells, where it catalyzes the conversion of arachidonic acid to 15-hydroxyeicosatetraenoic acid (15-HETE) involved in various airway inflammatory diseases. Interleukin (IL)-4 and IL-13 induce ALOX15 expression by activating Jak2 and Tyk2 kinases as well as signal transducers and activators of transcription (STATs) 1/3/5/6. ALOX15 up-regulation and subsequent association with phosphati...
Source: Allergy, Asthma and Immunology Research - Category: Allergy & Immunology Authors: Source Type: research
In this study, we examined SGK1 expression and its possible pathogenic roles in chronic rhinosinusitis (CRS).METHODS: Immunohistochemistry, western blotting, Bio-Plex assay, enzyme-linked immunosorbent assays, and quantitative real-time polymerase chain reaction were performed to assess protein and gene expression levels. The mRNA expression levels of SGK1 and interleukin-6 (IL-6) were extracted from a CRS database to perform correlation analysis. Stable cell lines with SGK1 overexpression (16HBE) and knockdown (A549) were constructed to investigate the interaction between SGK1 and IL-6 in vitro.RESULTS: SGK1 exhibited str...
Source: Allergy, Asthma and Immunology Research - Category: Allergy & Immunology Authors: Source Type: research
Allergy Asthma Immunol Res. 2021 Sep;13(5):684-696. doi: 10.4168/aair.2021.13.5.684.ABSTRACTArachidonic acid 15-lipoxygenase (ALOX15) is an enzyme that can oxidize polyunsaturated fatty acids. ALOX15 is strongly expressed in airway epithelial cells, where it catalyzes the conversion of arachidonic acid to 15-hydroxyeicosatetraenoic acid (15-HETE) involved in various airway inflammatory diseases. Interleukin (IL)-4 and IL-13 induce ALOX15 expression by activating Jak2 and Tyk2 kinases as well as signal transducers and activators of transcription (STATs) 1/3/5/6. ALOX15 up-regulation and subsequent association with phosphati...
Source: Allergy, Asthma and Immunology Research - Category: Allergy & Immunology Authors: Source Type: research
In this study, we examined SGK1 expression and its possible pathogenic roles in chronic rhinosinusitis (CRS).METHODS: Immunohistochemistry, western blotting, Bio-Plex assay, enzyme-linked immunosorbent assays, and quantitative real-time polymerase chain reaction were performed to assess protein and gene expression levels. The mRNA expression levels of SGK1 and interleukin-6 (IL-6) were extracted from a CRS database to perform correlation analysis. Stable cell lines with SGK1 overexpression (16HBE) and knockdown (A549) were constructed to investigate the interaction between SGK1 and IL-6 in vitro.RESULTS: SGK1 exhibited str...
Source: Allergy, Asthma and Immunology Research - Category: Allergy & Immunology Authors: Source Type: research
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