Vitamin C Deficiency Inhibits Nonalcoholic Fatty Liver Disease Progression through Impaired de Novo Lipogenesis
Despite the increasing clinical importance of nonalcoholic fatty liver disease (NAFLD), little is known about its underlying pathogenesis or specific treatment. The senescence marker protein 30 (SMP30), which regulates the biosynthesis of vitamin C (VC) in many mammals, except primates and humans, was recently recognized as a gluconolactonase. However, the precise relation between VC and lipid metabolism in NAFLD is not completely understood. Therefore, we aimed to clearly reveal the role of VC in NAFLD progression.
Source: American Journal of Pathology - Category: Pathology Authors: Seoung-Woo Lee, Su-Min Baek, Kyung-Ku Kang, A-Rang Lee, Tae-Un Kim, Seong-Kyoon Choi, Yoon-Seok Roh, Il-Hwa Hong, Sang-Joon Park, Tae-Hwan Kim, Kyu-Shik Jeong, Jin-Kyu Park Tags: Regular article Source Type: research