Hemophagocytic Lymphohistiocytosis in Adult and Pediatric Patients: Perspectives from a Tertiary Care Center

Hemophagocytic lymphohistiocytosis (HLH) describes a group of syndromes associated with immune system overstimulation.1 These syndromes can be divided into primary/familial and secondary/reactive.1 Primary HLH results from genetic mutations, while secondary HLH is attributed to viral infection, malignancy or autoimmune condition.1 Diagnosis and management is based on HLH-2004, the most widely used diagnostic criteria of HLH.2 Our study reviews adult and pediatric patients with HLH at our institution to improve understanding of this condition.
Source: Annals of Allergy, Asthma and Immunology - Category: Allergy & Immunology Authors: Source Type: research