Learning, Neurogenesis, and Effects of Flavonoids on Learning

Mini Rev Med Chem. 2021 Jul 7. doi: 10.2174/1389557521666210707120719. Online ahead of print.ABSTRACTLearning and memory are two of our mind's most magical abilities. Different brain regions have roles in processing and storing different types of memories. The hippocampus is the part of the brain responsible for receiving information and storing it in the neocortex. One of the most impressive characteristics of the hippocampus is its capacity for neurogenesis, which is a process in which new neurons are produced and then transformed into mature neurons and finally integrated into neural circuits. The neurogenesis process in the hippocampus, an example of neuroplasticity in the adult brain, is believed to aid hippocampal-dependent learning and memory. New neurons are constantly produced in the hippocampus and integrated into the pre-existing neuronal network; this allows old memories already stored in the neocortex to be removed from the hippocampus and replaced with new ones. Factors affecting neurogenesis in the hippocampus may also affect hippocampal-dependent learning and memory. The flavonoids can particularly exert powerful actions in mammalian cognition and improve hippocampal-dependent learning and memory by positively affecting hippocampal neurogenesis.PMID:34238155 | DOI:10.2174/1389557521666210707120719
Source: Mini Reviews in Medicinal Chemistry - Category: Chemistry Authors: Source Type: research