Genes, Vol. 12, Pages 1070: SARS-CoV-2 Infection and Emery-Dreifuss Syndrome in a Young Patient with a Family History of Dilated Cardiomyopathy

Genes, Vol. 12, Pages 1070: SARS-CoV-2 Infection and Emery-Dreifuss Syndrome in a Young Patient with a Family History of Dilated Cardiomyopathy Genes doi: 10.3390/genes12071070 Authors: Irina Magdalena Dumitru Nicoleta Dorina Vlad Sorin Rugina Nicoleta Onofrei Sabina Gherca Marian Raduna Aurel Trana Mirela Dumitrascu Elena Popovici Mircea Bajdechi Lucia Zekra Roxana Carmen Cernat Emery–Dreifuss muscular dystrophy (EDMD) is a rare genetic disease that affects the musculoskeletal system, including the heart, causing rhythm disorders and cardiomyopathy, sometimes requiring an implantable cardioverter-defibrillator (ICD) or heart transplantation due to severe heart damage. The case described herein concerns a 16-year-old girl, with grade II obesity, without other known pathological antecedents or cardiac pathology diagnosis given an annual history of cardiological investigations. She was admitted to the Infectious Diseases Department with SARS-CoV-2 virus infection. The anamnesis showed that the cardiological investigations performed in the past were completed due to the medical history antecedents of her sister, who had been diagnosed with dilated cardiomyopathy, having undergone the placement of an ICD and a heart transplant. Numerous investigations were performed during hospitalization, which revealed high levels of high-sensitive cardiac troponin I (hs-cTnI), creatine kinase (CK) and N-terminal pro b-type natriuretic peptide (NT-proBNP). Dynami...
Source: Genes - Category: Genetics & Stem Cells Authors: Tags: Case Report Source Type: research