Insufficient ablation promotes the metastasis of residual non-small cell lung cancer (NSCLC) cells via upregulating carboxypeptidase A4

CONCLUSIONS: This study demonstrates that sublethal heat stimulus caused by insufficient ablation can promote EMT and enhance the metastatic capacity of NSCLC. CPA4 plays an important role in these biological processes. Inhibition of CPA4 might be of great significance for improving early-stage NSCLC survival after ablation.PMID:34233564 | DOI:10.1080/02656736.2021.1947530

Source: International Journal of Hyperthermia - July 8, 2021 Category: Internal Medicine Authors: Peng Yan Xiaoli Lyu Sinian Wang Suhe Dong Zheng Zhu Bo Cheng Yuping Sun Qisheng Jiang Jie Liu Fengsheng Li Source Type: research