BioBonds Use Wall Street Tools to Fund Medical Research

Karen Petrou invented a new funding model for curing blindness. Proposed legislation aims to apply it to medical research more generally.
Source: NYT Health - Category: Consumer Health News Authors: Tags: Clinical Trials Drugs (Pharmaceuticals) Law and Legislation Petrou, Karen Shaw Research Lobbying and Lobbyists Health and Human Services Department Rush, Bobby L Fitzpatrick, Brian K (1973- ) Source Type: news

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Presentation Description: Diabetic retinopathy is the leading cause of blindness in working age adults in the United States. It is challenging to address in both rural and urban underserved settings, which suffer from shortages of eye specialists. This talk will describe the approach taken to address this condition in a medically underserved area (South Los Angeles) by researchers in the Center for Biomedical Informatics at Charles R. Drew University of Medicine and Science, using telehealth and machine learning on data from patient electronic health records. Speaker Bio: Omolola Ogunyemi, PhD, FACMI is the Director of ...
Source: Videocast - All Events - Category: General Medicine Tags: Upcoming Events Source Type: video
Conclusion: The plasma levels of citrulline, creatinine, arginine, and aminoadipic acid were significantly changed in ROP patients. These metabolites could be considered potential biomarkers of ROP, and their related metabolic pathways might be involved in ROP pathogenesis.PMID:34522185 | PMC:PMC8436098 | DOI:10.7150/ijms.63603
Source: International Journal of Medical Sciences - Category: Biomedical Science Authors: Source Type: research
Conclusion and recommendationPost-surgical trichiasis, lack of commitment from government officials and negative perception of patients towards the disease were considered as the reported barriers for implementation of trachomatous trichiasis. Closely supervising the integrated eye care workers would be the first task for district health offices to increase the uptake and improve the quality of service. Logistics and supplies should be made available and adequate to address all affected people in the community.
Source: PLoS Neglected Tropical Diseases - Category: Tropical Medicine Authors: Source Type: research
Lifestyle Genom. 2021 Sep 8:1-9. doi: 10.1159/000518489. Online ahead of print.ABSTRACTBACKGROUND: For thousands of years, disabilities due to nutrient deficiencies have plagued humanity. Rickets, scurvy, anemia, stunted growth, blindness, and mental handicaps due to nutrient deficiencies affected up to 1/10 of the world's population prior to 1900. The discovery of essential amino acids, vitamins, and minerals, in the early 1900s, led to a fundamental change in our understanding of food and a revolution in human health. Widespread vitamin and mineral supplementation, the development of recommended dietary allowances, and t...
Source: Genomics Proteomics ... - Category: Genetics & Stem Cells Authors: Source Type: research
People with macular degeneration, cataracts and diabetes-related eye disease at greater riskMillions of people with eye conditions including age-related macular degeneration, cataracts and diabetes-related eye disease have an increased risk of developing dementia, new research shows.Vision impairment can be one of the first signs of the disease, which is predicted to affect more than 130 million people worldwide by 2050.Continue reading...
Source: Guardian Unlimited Science - Category: Science Authors: Tags: Medical research Health Dementia Blindness and visual impairment Society Source Type: news
£200m project to eliminate avoidable blindness and disfigurement in Africa ends after funding is prematurely axedA chandelier sparkling in the background, the grandeur of Downing Street gleaming behind him, Boris Johnson looks into the camera and speaks with solemnity. He is marking World Neglected Tropical Diseases Day, he says, to raise awareness of these “terrible afflictions … which impose an immense burden of suffering in developing countries”.Huge progress has been made, he says, in the fight against the diseases, not least as a result of British aid to some of the poorest parts of the world....
Source: Guardian Unlimited Science - Category: Science Authors: Tags: Global development Infectious diseases Medical research Microbiology Science Africa Aid World news Blindness and visual impairment Health Source Type: news
AbstractAutoimmune uveitis is an inflammatory disease of the eye and is one of the major causes of blindness worldwide. Experimental autoimmune uveoretinitis (EAU) constitutes an animal disease model of human endogenous uveitis. In our study, we investigated the immunomodulatory effect of dimethyl fumarate (DMF) using bovine retinal extract-induced uveitis in a FemaleWistar rats. To evaluate the in vivo efficacy, FemaleWistar rats were divided into seven experimental groups: control group (n = 5), consisting of non-immunized animals; Uveoretinitis (n = 5), and DMF/Uveoretinitis groups (n ...
Source: Inflammopharmacology - Category: Drugs & Pharmacology Source Type: research
Appl Ergon. 2021 Sep 9;98:103578. doi: 10.1016/j.apergo.2021.103578. Online ahead of print.ABSTRACTAviation places significant demands on pilots' perceptual and attentional capacities. The avoidance of other objects both on the ground and in the air is critical to safe flight. Research on automobile driving has revealed the occurrence of 'inattentional blindness' (IB) whereby objects clearly located within the visual field may not detected when drivers are concurrently engaged in another attention capturing task such as a cellphone conversation. Almost no comparable research has been conducted within the aviation domain de...
Source: Applied Ergonomics - Category: Occupational Health Authors: Source Type: research
AbstractNeuronal ceroid lipofuscinoses (NCLs) collectively account for the highest prevalence of inherited neurodegenerative diseases in childhood. This disease group is classified by the deposition of similar autofluorescence storage material in lysosomes that is accompanied by seizures, blindness and premature mortality in later disease stages. Defects in several genes affecting various proteins lead to NCL, one of them being CLN6, a transmembrane protein resident in the endoplasmic reticulum. Dysfunctionality of CLN6 causes variant late infantile NCL (vLINCL). The function of CLN6 and how its deficiency affects lysosoma...
Source: Proteomics - Category: Biochemistry Authors: Tags: RESEARCH ARTICLE Source Type: research
Worldwide, the prevalence of type 2 diabetes is increasing due to an aging population and increasing obesity levels [1]. As a consequence, it is estimated that the prevalence of diabetic retinopathy, a common microvascular complication of diabetes [2], will grow from 126.6 million in 2011 to 191.0 million by 2030 [3,4]. Diabetic retinopathy can cause vision problems including vitreous haemorrhage, retinal detachment, glaucoma and blindness [2]. Regular diabetic retinopathy screening leads to the earlier detection of retinopathy and treatment that can prevent or delay the development of diabetes-related blindness [5].
Source: Primary Care Diabetes - Category: Primary Care Authors: Tags: Original research Source Type: research
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