Short-Acting Beta Agonist Overuse'a Global Public Health Issue'Short-Acting Beta Agonist Overuse'a Global Public Health Issue '
Overreliance on SABAs and underuse of inhaled corticosteroids are associated with increased risk of exacerbations and asthma-related death.Medscape Medical News
Higher body mass index tied to poor response to inhaled corticosteroids
Exp Ther Med. 2021 Nov;22(5):1239. doi: 10.3892/etm.2021.10674. Epub 2021 Sep 1.ABSTRACTAsthma diagnosis and management remains a challenging task for the medical community. The aim of the present study was to present the functional and inflammatory profiles of patients with difficult-to-treat asthma in a real-life clinical setting referred to the specialized asthma clinic at the University Hospital of Heraklion. The registry included a cohort of 267 patients who were referred to the severe asthma clinic. Patients were assessed with emphasis on the history of allergies, nasal polyposis or other comorbidities. Blood testing...
CONCLUSION: AD patients have a higher incidence of fractures. Severe AD is independently associated with fractures.PMID:34537357 | DOI:10.1016/j.anai.2021.09.004
Ann Allergy Asthma Immunol. 2021 Sep 2:S1081-1206(21)01024-3. doi: 10.1016/j.anai.2021.08.416. Online ahead of print.ABSTRACTBACKGROUND: Confirmation of effectiveness of asthma biologics in the real-world is desirable as patient characteristics and experiences may differ from those included in randomized controlled trials.OBJECTIVE: Evaluate real-world effectiveness of asthma biologics and identify predictors of response.METHODS: We performed a retrospective study in patients with severe asthma receiving biologics. The primary outcome was change in clinically significant exacerbations at 12 months after starting biologic t...
Conflicting evidence is currently available concerning the impact on asthma exacerbation of triple inhaled corticosteroid (ICS)/long-acting β2-adrenoceptor agonist (LABA)/long-acting muscarinic receptor antagonist (LAMA) fixed-dose combination (FDC). Since meta-analyses allow settling controversies of apparently inconsistent results, we performed a network meta-analysis of phase III randomised controlled trials including 9535 patients to assess the effect of ICS/LABA/LAMA combinations in uncontrolled asthma. Triple combination therapies with an ICS administered at high dose (HD) were more effective (p
A 38 year-old Chinese male was seen in Allergy clinic for poorly controlled atopic dermatitis (AD) since his childhood. This initially began as flexural eczema that became more widespread and severe with lichenification in his 30s. He has a background history of well-controlled allergic rhinitis. Management consisted of allergen minimization strategies, regular emollients, and regular topical corticosteroids. He had trailed escalating doses of azathioprine which resulted in cytopenias but minimal improvement in his eczema.
A 38-year-old Chinese man was seen in an allergy clinic for poorly controlled atopic dermatitis (AD) since his childhood. This initially began as flexural eczema that became more widespread and severe with lichenification in his 30s. He has a background history of well-controlled allergic rhinitis. Management consisted of allergen minimization strategies, regular emollients, and regular topical corticosteroids. He had trialed escalating doses of azathioprine which resulted in cytopenias and minimal improvement in his eczema.
Conclusion This is the first RCT demonstrating that genotype-driven asthma prescribing is associated with a significant improvement in a clinical outcome compared to standard care. Adolescents with the AA homozygous genotype benefited most. The potential role of such β2-adrenoceptor genotype directed therapy in younger and more severe childhood asthma warrants further exploration.
CONCLUSION: Inhaled corticosteroids are highly effective in preventing exacerbations of asthma. Multiple dosing strategies have been demonstrated to reduce exacerbation risk, allowing for a personalization of approaches based upon individual patient phenotypes and preferences.PMID:34400314 | DOI:10.1016/j.anai.2021.08.014