The Million-Person Challenge

Let's face it, we've all read and seen things on social media that would make etiquette expert Emily Post's head spin -- perhaps we've even been guilty of posting some egregious things ourselves, maybe when we've had a little too much caffeine or on a spontaneous whim that we realize was a mistake in hindsight. In today's world, it seems cool to overshare and bare it all. Sex, politics, religion -- everything that was once too taboo for public conversation is now open ground for all the world to see. Yet there remains a topic rarely shared without judgment, one that continues to face tremendous stigma: addiction. Admit it, when was the last time you had a favorable response to a post in which someone openly shared their turmoil with drug or alcohol addiction (not just the occasional late-night partying), or the plight of a loved one? Perhaps you have a connection who posts about it -- and receives their fair share of scoffing and criticism. Truth is, it's one subject that is still considered too embarrassing an admission to discuss openly, yet data indicates we all know someone who struggles with drinking or drugs. We're not talking (posting, sharing) about it and we're not getting the help we need. That leads me to wonder -- why not? In 2013, nearly 23 million Americans met diagnostic criteria for substance (drug or alcohol) abuse or dependence. And in that year, 2.5 million of them received treatment. That means that over 20 million Americans experienced enough symptoms...
Source: Healthy Living - The Huffington Post - Category: Consumer Health News Source Type: news

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ConclusionsThis study shows that reduction of CTRP3 concentrations is likely to bring a concomitant increase in risk of diabetes in obese and normal body weight young adults. Decrease in CTRP3 concentration may have an essential role in the pathophysiology of metabolic disorders concomitant to obesity.
Source: Diabetes and Metabolic Syndrome: Clinical Research and Reviews - Category: Endocrinology Source Type: research
Publication date: Available online 19 October 2018Source: Pharmacology &TherapeuticsAuthor(s): A.D. Dobrian, M.A. Morris, D.A. Taylor-Fishwick, T.R. Holman, Y. Imai, R.G. Mirmira, J.L. NadlerAbstract12-lipoxygenase (12-LOX) is one of several enzyme isoforms responsible for the metabolism of arachidonic acid and other poly-unsaturated fatty acids to both pro- and anti-inflammatory lipid mediators. Mounting evidence has shown that 12-LOX plays a critical role in the modulation of inflammation at multiple checkpoints during diabetes development. Due to this, interventions to limit pro-inflammatory 12-LOX metabolites eithe...
Source: Pharmacology and Therapeutics - Category: Drugs & Pharmacology Source Type: research
We describe the effects of drug exposure during development, implications for understanding psychosis and cannabis use disorder, and methodological considerations. Greater understanding of the precise mechanisms underlying the effects of cannabis may also give rise to new treatment targets.
Source: Pharmacology and Therapeutics - Category: Drugs & Pharmacology Source Type: research
ConclusionLack of drug efficacy, inappropriate drug adherence and patient knowledge were the major TRPs identified via delivering the MMR service to post-stroke patients. The identified TRPs highlights the importance of the MMR service, and supports planning future strategies aimed at decreasing the incidence of strokes.
Source: Saudi Pharmaceutical Journal - Category: Drugs & Pharmacology Source Type: research
In this study, glibenclamide silica monolithic xerogel implants for subdermal application (GMSIx) were developed using the sol-gel technique for matrix synthesis with TEOS with different drying conditions (environmental, 60, 90, and 120 °C, which were named as GMSIE, GMSI60, GMSI90, and GMSI120, respectively). The inclusion of the drug in monoliths was monitored by DSC, FTIR, and PXRD. The effect of drying conditions on the morphology, moisture content, hardness, dosage uniformity, surface characteristics, and drug release mechanism of glibenclamide from the matrices was systematically investigated. Oral Glucose Tole...
Source: Materials Science and Engineering: C - Category: Materials Science Source Type: research
Publication date: Available online 19 October 2018Source: Neuroscience &Biobehavioral ReviewsAuthor(s): Aleksandra M. Herman, Theodora DukaAbstractAlcohol misuse is a major public concern. Impulsivity has been recognised as a significant risk factor predisposing for the initiation of alcohol use, continuation and excessive alcohol use. Evidence suggests that impulsivity is also a result of both acute alcohol intoxication and long-term alcohol abuse. The multifaceted character of impulsivity and the various ways of assessing it in humans and animal models, hampers the full understanding of how impulsivity relates to alc...
Source: Neuroscience and Biobehavioral Reviews - Category: Neuroscience Source Type: research
Conclusions: This is the first study to demonstrate a moderating role of childhood trauma on the relationship between inhibitory control and stress-related ACC activation. Childhood trauma may portend neurodevelopmental changes that impede recruitment of control-associated ACC-functioning during distress, which may relate to dysregulation of stress-induced affective responses. Further work is needed to elucidate relationships between childhood trauma and addictive behaviors precipitated by stress.
Source: NeuroImage - Category: Neuroscience Source Type: research
In conclusion, Ffar1 expression is markedly down-regulated under diabetic conditions which is accompanied by decreased expression of Pdx1. Furthermore, it is likely that Pdx1 is a regulator of Ffar1 expression in β-cells. PMID: 30333365 [PubMed - as supplied by publisher]
Source: Endocrine Journal - Category: Endocrinology Tags: Endocr J Source Type: research
There’s an argument that has been batted around in online conversations, one that I thought that, because it was so patently absurd and so readily disproven, it would simply disappear into the blogosphere . . . but it hasn’t. So let’s talk about this idea. The idea goes like this: Because glyphosate is liberally applied to wheat, including its application as a desiccant and for weed control pre-planting, during maturation, and pre-harvest, the high concentrations of this herbicide in wheat products are the cause for all the problems that emerge with wheat consumption. It means that, minus glyphosate, whea...
Source: Wheat Belly Blog - Category: Cardiology Authors: Tags: News & Updates gluten-free glyphosate grain-free grains Inflammation roundup undoctored wheat belly Source Type: blogs
Conclusions: This article provides recommendations for researchers and federal funders to ensure respect for the contributions of TEK to research and to ensure equity and self-determination for Tribal nations who participate in research. https://doi.org/10.1289/EHP858 Received: 22 July 2016 Revised: 10 April 2017 Accepted: 27 April 2017 Published: 29 August 2017 Address correspondence to S. Finn, National Institute of Environmental Health Sciences, Division of Extramural Research and Training, Population Health Branch, 530 Davis Drive, Durham, NC 27713 USA. Telephone: 919-541-4258. Email: finns@niehs.nih.gov The auth...
Source: EHP Research - Category: Environmental Health Authors: Tags: Commentary Source Type: research
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