The Million-Person Challenge
Let's face it, we've all read and seen things on social media that would make etiquette expert Emily Post's head spin -- perhaps we've even been guilty of posting some egregious things ourselves, maybe when we've had a little too much caffeine or on a spontaneous whim that we realize was a mistake in hindsight. In today's world, it seems cool to overshare and bare it all. Sex, politics, religion -- everything that was once too taboo for public conversation is now open ground for all the world to see. Yet there remains a topic rarely shared without judgment, one that continues to face tremendous stigma: addiction. Admit it, when was the last time you had a favorable response to a post in which someone openly shared their turmoil with drug or alcohol addiction (not just the occasional late-night partying), or the plight of a loved one? Perhaps you have a connection who posts about it -- and receives their fair share of scoffing and criticism. Truth is, it's one subject that is still considered too embarrassing an admission to discuss openly, yet data indicates we all know someone who struggles with drinking or drugs. We're not talking (posting, sharing) about it and we're not getting the help we need. That leads me to wonder -- why not? In 2013, nearly 23 million Americans met diagnostic criteria for substance (drug or alcohol) abuse or dependence. And in that year, 2.5 million of them received treatment. That means that over 20 million Americans experienced enough symptoms...
ConclusionOur study suggests a VDR-mediated metabolic cross-talk between gut and adipose tissue, which significantly contributes to systemic lipid homeostasis. These results have important implications for use of the intestinal VDR as a therapeutic target for obesity and associated disorders.
This study demonstrates that CCL2 is a key molecule for the development of metabolic and histological alterations in the liver of mice sensitive to the development of hyperlipidemia and hepatic steatosis, a finding with potential to identify new therapeutic targets in liver diseases.
Publication date: Available online 21 March 2019Source: MitochondrionAuthor(s): Hamza El Hadi, Roberto Vettor, Marco RossatoAbstractCardiovascular disease is the leading cause of diabetes-related morbidity and mortality. It is widely accepted that heart failure risk is increased in diabetic patients even after adjusting for coronary artery disease and hypertension. Mitochondria are the center of fatty acid (FA) and glucose metabolism and thus are likely to be impacted by impaired metabolism associated with diabetes. Although the cause of this increased heart failure risk is multifactorial, increasing evidence points toward...
ConclusionsO-GlcNAcylation significantly modified STRA6 and RALDH1, suppressed RBP4 binding activity, and disrupted retinol signals in the kidney of diabetes.General significanceThis study first indicates that STRA6-retinol signals were directly disrupted by O-GlcNAcylation in diabetic kidney.
Phys. Chem. Chem. Phys., 2019, Accepted Manuscript DOI: 10.1039/C9CP00752K, PaperPaulo C. D. Mendes, Rafael Costa-Amaral, Janaina F Gomes, Juarez L. F. Da Silva Experimentally, steric and inductive effects have been suggested as important factors on alcohol adsorption and reactivity on transition-metal (TM) surfaces, however, the atomistic understanding of the behavior of alcohols in... The content of this RSS Feed (c) The Royal Society of Chemistry
Faraday Discuss., 2019, Accepted Manuscript DOI: 10.1039/C8FD00223A, PaperYong Zhao, Kenneth T. Kongstad, Yueqiu Liu, he chenghua, Dan Staerk Medicinal plants have been widely used as (poly)pharmacological remedies and constitute a rich source for anti-diabetic drug discovery. In the present study, forty medicinal plant samples collected in China were... The content of this RSS Feed (c) The Royal Society of Chemistry
Sweat works like blood for health monitoring University of Cincinnati, Abbott Diabetes Care, Salimetrics LLC, Eccrine Systems, Inc. Climate change impact when temperature determines ...This is an NSF Multimedia Gallery item.
Conclusion: Therefore, considering the role of myonectin in increasing fatty acid uptake, exercise training can play an essential role in decreasing obesity-related diseases and metabolic syndrome; this effect is partly related to the roles of myonectin. Therefore, the use of this type of exercise is recommended to reduce the risk of diseases associated with obesity and metabolic syndrome. PMID: 30894898 [PubMed - in process]
We examined acceptability and feasibility of a tablet application ("App") to record self-reported alcohol consumption among Aboriginal and Torres Strait Islander Australians. Four communities (1 urban; 3 regional/remote) tested the App, with 246 adult part...
Conclusions: This article provides recommendations for researchers and federal funders to ensure respect for the contributions of TEK to research and to ensure equity and self-determination for Tribal nations who participate in research. https://doi.org/10.1289/EHP858 Received: 22 July 2016 Revised: 10 April 2017 Accepted: 27 April 2017 Published: 29 August 2017 Address correspondence to S. Finn, National Institute of Environmental Health Sciences, Division of Extramural Research and Training, Population Health Branch, 530 Davis Drive, Durham, NC 27713 USA. Telephone: 919-541-4258. Email: email@example.com The auth...
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