High-dose irradiation in combination with non-ablative low-dose radiation to treat metastatic disease after progression on immunotherapy: results of a phase II trial

CONCLUSIONS: HD-RT plus LD-RT safely improved lesion-specific response in patients with immune resistant solid tumors by promoting infiltration of effector immune cells into the tumor microenvironment.PMID:34237343 | DOI:10.1016/j.radonc.2021.06.037

Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - July 8, 2021 Category: Radiology Authors: Roshal R Patel Kewen He Hampartsoum B Barsoumian Joe Y Chang Chad Tang Vivek Verma Nathan Comeaux Stephen G Chun Saumil Gandhi Mylene T Truong Jeremy J Erasmus David S Hong Percy P Lee Matthew S Ning Quynh-Nhu Nguyen John V Heymach Mehmet Altan George Blu Source Type: research