SARS-CoV-2 neutralising antibody testing in Europe: towards harmonisation of neutralising antibody titres for better use of convalescent plasma and comparability of trial data
Euro Surveill. 2021 Jul;26(27). doi: 10.2807/1560-7917.ES.2021.26.27.2100568.ABSTRACTWe compared the performance of SARS-CoV-2 neutralising antibody testing between 12 European laboratories involved in convalescent plasma trials. Raw titres differed almost 100-fold differences between laboratories when blind-testing 15 plasma samples. Calibration of titres in relation to the reference reagent and standard curve obtained by testing a dilution series reduced the inter-laboratory variability ca 10-fold. The harmonisation of neutralising antibody quantification is a vital step towards determining the protective and therapeutic levels of neutralising antibodies.PMID:34240697 | DOI:10.2807/1560-7917.ES.2021.26.27.2100568
Source: Euro Surveill - Category: Infectious Diseases Authors: Dung Nguyen Peter Simmonds Maurice Steenhuis Elise Wouters Daniel Desmecht Mutien Garigliany Marta Romano Cyril Barbezange Piet Maes Bram Van Holm Joaqu ín Mendoza Salvador Oyonarte Anders Fomsgaard Ria Lassauni ère Eva Zusinaite Katarina Resman Rus Tat Source Type: research