SARS-CoV-2 neutralising antibody testing in Europe: towards harmonisation of neutralising antibody titres for better use of convalescent plasma and comparability of trial data

Euro Surveill. 2021 Jul;26(27). doi: 10.2807/1560-7917.ES.2021.26.27.2100568.ABSTRACTWe compared the performance of SARS-CoV-2 neutralising antibody testing between 12 European laboratories involved in convalescent plasma trials. Raw titres differed almost 100-fold differences between laboratories when blind-testing 15 plasma samples. Calibration of titres in relation to the reference reagent and standard curve obtained by testing a dilution series reduced the inter-laboratory variability ca 10-fold. The harmonisation of neutralising antibody quantification is a vital step towards determining the protective and therapeutic levels of neutralising antibodies.PMID:34240697 | DOI:10.2807/1560-7917.ES.2021.26.27.2100568
Source: Euro Surveill - Category: Infectious Diseases Authors: Source Type: research