Apolipoprotein E4, amyloid, and cognition in Alzheimer's and Lewy body disease

In conclusion, the impact of APOE4 on disease risk depends on its effects on β-amyloid deposition, and APOE4 is associated with β-amyloid deposition regardless of the clinical diagnosis. However, it interacts with typical LBD to cause occipital β-amyloid deposition.PMID:34242895 | DOI:10.1016/j.neurobiolaging.2021.06.004

Source: Neurobiology of Aging - July 9, 2021 Category: Geriatrics Authors: Jin Ho Jung Seun Jeon Kyoungwon Baik Yang Hyun Lee Seok Jong Chung Han Soo Yoo Seong Ho Jeong Young H Sohn Phil Hyu Lee Byoung Seok Ye Source Type: research